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KMID : 0615720130300040095
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Jouranl of Korean Acupuncture and Moxibustion society
2013 Volume.30 No. 4 p.95 ~ p.105
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Effects of Curcuma longa LINNE Pharmacopuncture at ST36 on Adjuvant Induced Arthritis in Rats
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Lee Ook-Jae
Lee Dong-Geun
Lee Ju-Hee
Lee Jung-Hun
Lee Sang-Hyun
Park Geun-Hee
Shin Jeong-Cheol
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Abstract
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Objectives : The objective of this study was to investigate the effects of Curcuma longa LINNE pharmacopuncture at ST36 on Complete Freund’s Adjuvant(CFA)-induced arthritis in rats.
Materials and methods : Arthritis was induced by injecting CFA subcutaneously into the left knee joint and paw, and Curcuma longa LINNE pharmacopuncture(CLL-A. 0.0343 μg/kg; CLL-B. 0.171 μg/kg; CLL-C. 0.343 μg/kg) was injected at ST36 each other day for 5 times beginning on day 10 after the CFA injection. Paw edema, withdrawal response, hematological, serological and histological observation were assessed.
Results : In paw edema volume all 3 groups(CLL-A, CLL-B, CLL-C) showed significant decrease compared to the CFA control group. In withdrawal response to reaction time and withdrawal response to force all 3 groups(CLL-A, CLL-B, CLL-C) showed significant increase compared to the CFA control group. In serum AST, group CLL-C showed significant decrease compared to the CFA control group. In histological observations, in all 3 groups, more normal chondrocytes were observed compared to the CFA control group and safranin O stain showed high positive reaction in the cartilage tissue close to the bone tissue.
Conclusions : The results suggest that Curcuma longa LINNE Pharmacopuncture at ST36 has a suppressing inflammation effect on Freund’s adjuvant arthritis in rats.
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KEYWORD
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Rheumatoid arthritis, Freund’s adjuvant arthritis, Curcuma longa LINNE pharmacopuncture, ST36.
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